Synthroid Uses, Dosage & Side Effects

Administration of sertraline in patients stabilized on SYNTHROID may result in increased SYNTHROID requirements. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased. Closely monitor coagulation tests to permit appropriate and timely dosage adjustments. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various gastrointestinal symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness, and wheezing.

1 Drugs Known to Affect Thyroid Hormone Pharmacokinetics

If you become pregnant while taking Synthroid, do not stop taking the medicine without your doctor’s advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Since thyroid hormone occurs naturally in the body, almost anyone can take levothyroxine. However, you may not be able to take this medicine if you have certain medical conditions. Consumption of certain foods may affect SYNTHROID absorption thereby necessitating adjustments in dosing see Dosage and Administration (2.1). Soybean flour, cottonseed meal, walnuts, and dietary fiber may bind and decrease the absorption of SYNTHROID from the gastrointestinal tract.

Synthroid – Clinical Pharmacology

• The recommended daily dosage of SYNTHROID in pregnant patients is described in Table 3.
• Many drugs can inhibit Synthroid’s adsorption by the body; other medications may increase or decrease its effectiveness once it is adsorbed.
• If you eat any of these on a regular basis, check with your doctor.
• Providing a complete list of medications to the doctor will help with getting the correct dose established for each individual patient.
• Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration.
• T4 absorption is increased by fasting, and decreased in malabsorption syndromes and by certain foods such as soybeans.

And even the way you take Synthroid can affect how much medicine your body is getting. It’s important to always take your medication exactly as your doctor prescribed. Levothroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Unithroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … NP Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid cancer …

• Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension.
• Closely monitor infants during the first 2 weeks of SYNTHROID therapy for cardiac overload and arrhythmias.
• Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of SYNTHROID see Warnings and Precautions (5.1) and Use in Specific Populations (8.4).

Label: SYNTHROID- levothyroxine sodium tablet

If so, advise them to stop biotin supplementation at least 2 days before assessing TSH and/or T4 levels. Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis. Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA.

• Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.
• Seizures have been reported rarely with the institution of levothyroxine therapy.
• For pregnant patients with pre-existing hypothyroidism, measure serum TSH and free-T4 as soon as pregnancy is confirmed and, at minimum, during each trimester of pregnancy.
• You should refer to the prescribing information for Synthroid for a complete list of interactions.

Stop biotin and biotin-containing supplements for at least 2 days before assessing TSH and/or T4 levels. Titrate the dose of SYNTHROID carefully and monitor response to titration to avoid these effects see DOSAGE AND ADMINISTRATION. Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see DOSAGE AND ADMINISTRATION, DRUG INTERACTIONS and CLINICAL PHARMACOLOGY. SYNTHROID may reduce the therapeutic effects of digitalis glycosides.

Closely monitor blood pressure and heart rate in these patients. synthroid reliability The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks. Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see DRUG INTERACTIONS.

Decreased Bone Mineral Density Associated With Thyroid Hormone Over-Replacement

Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter. Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … It may take several weeks before your body starts to respond to Synthroid. Your child’s dose needs may change if the child gains or loses weight. SYNTHROID is contraindicated in patients with uncorrected adrenal insufficiency see Warnings and Precautions (5.4). Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see Drug Interactions (7.1).

DOSAGE AND ADMINISTRATION

Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of SYNTHROID see WARNINGS AND PRECAUTIONS and Use In Specific Populations. Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. SYNTHROID is indicated in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

With hypothyroidism, the thyroid is unable to produce enough thyroid hormone. Certain foods and medications can interfere with the way your body absorbs or processes Synthroid. Be sure to let your doctor know if there are any changes to your diet or to the medications you take. You can see a list of the foods and medications that can affect the way Synthroid works here.

For adult patients with primary hypothyroidism, titrate until the patient is clinically euthyroid and the serum TSH returns to normal see Recommended Dosage And Titration. Synthroid is prescribed in tablets that range from 25 to 300 mcg in strength and is usually taken once a day with a full glass of water (about 8 ounces) 30 to 60 minutes before breakfast for best adsorption into the body. Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension. Doctors often may have to slowly increase the dose; patients should not increase or decrease this medication themselves. Because some preparations of the drug may contain iodine or lactose, patients should tell their doctors about such allergies or reactions to these components.